Drug & Supplement Interaction Checker
Check if your current medications interact with supplements, herbs, or natural remedies. Start typing to search from our database of 120+ medications and 160+ supplements.
Prescription drugs, OTC medicines
Vitamins, herbs, natural remedies
Medical Disclaimer: This tool provides educational information based on known interactions in our database of 160+ natural remedies. It does not cover all possible interactions and should not replace professional medical advice. Always consult your healthcare provider or pharmacist before combining medications with supplements or herbal remedies.
Frequently Asked Questions
What drug-herb interactions does this checker cover?
Our checker uses AI analysis to evaluate interactions between any medication and supplement combination. It covers prescription drugs, over-the-counter medicines, herbal remedies, vitamins, and supplements across phytotherapy, TCM, Ayurveda, homeopathy, and nutritional therapy traditions.
How accurate is the interaction data?
The checker is powered by clinical AI trained on pharmacological literature and interaction databases. While it identifies well-established and evidence-based interactions, it may not cover every possible combination. It is designed as an educational screening tool, not a clinical decision-making system.
Is this tool a replacement for medical advice?
No. This tool provides educational information to help you have more informed conversations with your healthcare provider. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making changes to your medication or supplement regimen.
Do I need an account to use the interaction checker?
No. The interaction checker is completely free and requires no account or registration. You can check as many combinations as you need.
What supplements interact with warfarin?
Warfarin has documented interactions with turmeric, ginkgo biloba, garlic supplements, fish oil at high doses, St. John's Wort, vitamin K2, cranberry supplements, and CBD oil. Our checker covers all of these.
Can I take supplements with antidepressants?
Many supplements are safe with antidepressants, but ashwagandha, melatonin, and St. John's Wort interact with various antidepressant classes. The specific combination matters, which is why checking each one individually is important.
What is the most dangerous supplement interaction?
St. John's Wort combined with immunosuppressants like cyclosporine has caused organ rejection in transplant patients. St. John's Wort with SSRIs can cause serotonin syndrome. These are among the most serious documented herb-drug interactions.
Should I stop supplements before surgery?
Many practitioners advise discontinuing garlic, ginkgo, ginseng, fish oil, and vitamin E 1-2 weeks before surgery due to increased bleeding risk. Valerian and kava may interact with anesthesia.
Do vitamins interact with prescription drugs?
Yes. Iron reduces thyroid medication absorption by up to 75%. Vitamin D interacts with thiazide diuretics. Vitamin K affects warfarin. Calcium blocks several antibiotics. Even common vitamins can have significant drug interactions.
Common Interactions People Check
Turmeric & Warfarin
Curcumin supplements can increase bleeding risk with blood thinners
Ashwagandha & SSRIs
Generally low risk, but one antidepressant class is a real concern
St. John's Wort & Birth Control
Can make oral contraceptives less effective through CYP3A4 induction
CBD Oil & Medications
Blocks CYP3A4 and CYP2C19, affecting blood thinners and seizure meds
Iron & Thyroid Meds
Take 4+ hours apart or lose up to 75% of levothyroxine absorption
Melatonin & Antidepressants
One specific SSRI can make a 3mg dose hit like 36mg
Ginkgo & Blood Thinners
Blocks platelet-activating factor, increasing bleeding risk
Berberine & Metformin
Both activate AMPK and lower blood sugar, doubling the effect
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