Reishi
Adaptogenic medicinal mushroom.
Why
Adaptogenic medicinal mushroom. RCT evidence for immune modulation and quality of life in cancer adjunct contexts; broader immunomodulation suggestive.
How it works
β-glucans and triterpenoids modulate immune-cell activity in preclinical models; clinical evidence concentrated in cancer-adjunct quality-of-life trials.
How to take
Dosage
Studied range: 1.5–9 g/day of standardized extract across trials. Heterogeneity is high, products vary widely in β-glucan content, no single regimen carries strong consensus.
Safety
Evidence
Jin 2016 Cochrane review (5 RCTs, n=373 cancer patients): Ganoderma lucidum as adjunct to conventional treatment was associated with higher likelihood of positive response and improved immune-cell function vs control, with limited effect on tumour response or mortality. Cochrane rated evidence as limited and low-quality; broader immunomodulation in healthy adults is suggestive but not established.
β-glucan content varies widely between products, and trial regimens are heterogeneous, no single dose or onset timeline carries strong consensus. Cochrane evidence is concentrated in cancer-adjunct quality-of-life trials rather than broad immunomodulation.
Where to get it
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