Nettle root
EMA-monograph root extract for BPH symptoms, often combined with saw palmetto in fixed European preparations.
Why
Nettle root (Urtica dioica radix), distinct from the more familiar nettle leaf, holds an EMA HMPC monograph for relief of lower urinary tract symptoms in BPH. The combined Urtica + Serenoa fixed preparation (PRO 160/120) has multiple RCTs showing IPSS improvements comparable to tamsulosin and finasteride in mild-to-moderate BPH. Nettle root monopreparations have a smaller but directionally consistent RCT base.
How it works
Lectins and lignans inhibit sex-hormone-binding globulin (SHBG) binding to prostatic membranes and reduce aromatase activity, modulating local androgen-oestrogen balance. Polysaccharides have anti-inflammatory effects on prostatic tissue. Mechanism is distinct from but complementary to saw palmetto's 5α-reductase inhibition.
Expected onset · IPSS improvement over 8–12 weeks
How to take
Dosage
Nettle root monoextract: 600–1,200 mg/day divided. Fixed combination (PRO 160/120): one capsule twice daily (160 mg Serenoa + 120 mg Urtica per capsule).
Timing
Twice daily with food
On the label
'Nettle root' or 'Urtica dioica radix' specifically, nettle leaf is for different indications (joint discomfort, allergic rhinitis). Named extracts: PRO 160/120 (fixed combo), Bazoton, Urtica Plus.
Ideal for
Adult men with mild-to-moderate BPH symptoms, after specialist evaluation; often used in fixed combination with saw palmetto.
Safety
Evidence
Safarinejad 2005 J Herb Pharmacother RCT (n=620 BPH): nettle root extract significantly improved IPSS, urinary flow and post-void residual vs placebo over 6 months. Engelmann 2006 head-to-head RCT: the PRO 160/120 Urtica + Serenoa fixed combination was non-inferior to tamsulosin 0.4 mg for IPSS improvement at 60 weeks. EMA classifies the root as Well-Established Use for BPH symptoms.
Where to get it
Shop Nettle root on AmazonSponsored · As an Amazon Associate, Healicus earns from qualifying purchases.