Lactobacillus reuteri DSM 17938
Strain-specific probiotic with meta-analysis support for reducing infant colic crying time.
Why
Lactobacillus reuteri DSM 17938 (a derivative of the original L. reuteri ATCC 55730, with the resistance plasmids removed) is the probiotic strain with the strongest evidence in infantile colic. The Sung 2018 meta-analysis of breastfed infants reported approximately 25 minutes/day reduction in crying time and increased treatment success at 21 days. Effect in formula-fed infants is less consistent, strain-specific and population-specific.
How it works
Produces reuterin, a broad-spectrum antimicrobial, with activity against gas-producing infant gut bacteria (E. coli, Klebsiella). Modulates substance P signalling in enteric neurons, possibly underlying the analgesic-on-colic effect.
Expected onset · Colic crying-time reduction often by day 7–14; effect window is the first 3 months
How to take
Dosage
Infants: 1 × 10⁸ CFU (5 drops) once daily. Adult use in functional dyspepsia or H. pylori adjunct trials uses higher doses; consult product label.
Timing
Once daily; for breastfed infants, often before a feed
On the label
Specifically 'L. reuteri DSM 17938' (BioGaia is the principal commercial source). Other L. reuteri strains are not equivalent.
Ideal for
Breastfed infants with colic (under paediatric guidance); adults exploring strain-specific probiotic options for functional GI symptoms.
Safety
Evidence
Sung 2018 Pediatrics individual-participant-data meta-analysis (4 RCTs, n=345 colicky infants): L. reuteri DSM 17938 reduced crying duration by ~25 min/day and doubled treatment success rate in breastfed infants vs placebo at 21 days. Effect smaller and less consistent in formula-fed infants, strain plus population both matter.
- Sung et al., Pediatrics 2018, Lactobacillus reuteri to treat infant colic: meta-analysis (individual-participant data)
- Indrio et al., JAMA Pediatr 2014, prophylactic use of probiotic for functional GI disorders in infants (RCT)
- Szajewska et al., J Pediatr Gastroenterol Nutr 2018, probiotics for the management of infantile colic: systematic review
Where to get it
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