SupplementModerate evidenceImmunity

Aloe vera topical

Meta-analysis support for first- and second-degree burn healing; less consistent for other indications.

Why

Aloe vera (Aloe barbadensis miller) gel from the leaf parenchyma has been used topically for burns for over two millennia. A systematic review and meta-analysis of RCTs in first- and second-degree burns reported shorter time to re-epithelialisation versus standard care. Other topical indications (psoriasis, oral mucositis, wound healing) have smaller and more mixed RCT bodies. Internal aloe latex (the yellow exudate) is distinct from the gel and is a stimulant laxative with safety concerns, not equivalent.

How it works

Polysaccharides (acemannan) stimulate macrophage cytokine release and fibroblast proliferation. Glycoproteins (aloctin A and B) promote epithelial cell migration. Salicylates and prostaglandin precursors contribute local anti-inflammatory effects.

Expected onset · Burn re-epithelialisation: faster than standard care across small RCTs, often within 7–10 days

How to take

Dosage

Topical gel: apply 2–3 times daily to the affected area. For burns: after initial cooling with running water and once oozing has stopped.

Timing

2–3 times daily during the symptomatic phase

On the label

'Aloe vera leaf gel' or '100% inner-leaf gel', distinct from 'aloe vera latex' or 'aloe whole-leaf juice'. Stabilised gel preparations preserve activity longer than fresh leaf.

Ideal for

Adults with first- and second-degree burns (after initial cooling), minor wounds, sunburn, or seeking soothing topical care.

Safety

Topical use generally safe. Allergic contact dermatitis possible. The aloe latex (yellow exudate) is a stimulant laxative, distinct from the topical gel; chronic internal use is not recommended due to colonic concerns and EFSA-flagged hydroxyanthracene safety. Topical use in third-degree or extensive burns requires emergency medical care, not aloe gel.

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Evidence

At a glance

Maenthaisong 2007 Burns systematic review (4 RCTs): aloe vera reduced burn-wound healing time by ~8.8 days vs control. Hekmatpou 2019 meta-analysis on wound healing concluded aloe vera accelerates closure across multiple small trials. The topical gel evidence is meaningfully stronger than the internal indications.

Where to get it

Shop Aloe vera topical on Amazon

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